古川・佐藤研究室, Laboratory of Glycobiology
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最近の研究トピックス

  1. Tagawa, M., Shirane, K., Yu, M., Sato, T., Furukawa, S., Mizuguchi, H., Kuji, R., Kawamura, K., Takahashi, N., Kato, K., Hayakawa, S., Sawada, S., and Furukawa, K. Enhanced expression of the β4-galactosyl transferase 2 gene impairs mammalian tumor growth. Cancer Gene Therapy, in press (2014).

  2. Hirano, K., Matsuda, A., Shirai, T., and Furukawa, K. Expression of LacdiNAc group on N-glycans among human tumors is complex. BioMed Res. Intern., in press (2014).

  3. Shirane, K., Kuji, R., Tareyanagi, C., Sato, T., Kobayashi, Y., Furukawa, S., Murata, T., Kubota, S., Ishikawa, Y., Segawa, K., and Furukawa, K. (2014) Gene expression levels of β4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells. Glycobiology, 24:532-541.

  4. Furukawa, K., Clausen, H., and Sato, T. β-1,4-galactosyltransferase 2, 3, 4, 5, 6 and 7. Handbook of Glycosyltransferases and Related Genes (2nd Version) (Taniguchi, T., Honke, K., Fukuda, M>, Narimatsu, H., Yamaguchi, Y., and Angata, T., eds.), Springer-Verlag, Tokyo, in press.

  5. Sato, T., and Furukawa, K. Expression and transcriptional regulation of β-1,4-galactosyltransferase genes in cancer. Glycoscience: Biology and Medcine (Taniguchi, N., Endo, T., Hart, G., Seeberger, P., and Wong, C-H., eds), Springer-Verlag, Tokyo, in press.

  6. Yazawa, S., Yokobori, T., Ueta, G., Ide, M., Altan, B., Thongprachum, A., Nishimura, T., Nakajima, T., Kominato, Y., Asao, T., Saniabadi, R., Furukawa, K., Kuwano H., Le Pendu, J., and Ushijima, H. (2014) Blood group substances as potential therapeutic agents for the prevention and treatment of infection with noroviruses proving novel binding patterns in human tissues. PLOSE ONE, 9 (2): e89071 (DOI: 10.1371/journal.pone. 0089071).

  7. Taus, C., Lucini, C., Sato, T., Furukawa, K., Grabherr, R., and Stau¬dacher, E. (2013) Snail UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase: Expression and characterization of the first snail-derived glycosyltransferase involved in O-glycosylation. Glycoconj. J., 30: 825-833.

  8. Furukawa, K., Tadokoro, T., Sato, M., and Yamada, E. (2012) Preparation of filter paper conjugated with high mannose-type glycans. Transaction on GIGAKU, Vol. 1, 1-5

  9. Komatsu, S., Kuji, R., Nanjo, Y., Hiraga, S., and Furukawa, K. (2012) Comprehensive analysis of endoplasmic reticulum-enriched fraction in root tips of soybean under flooding stress using proteomics techniques. J. Proteomics, 77: 531-560.

  10. Paschinger, K., Razzazi-Fazeli, E., Furukawa, K., and Wilson, I. B. H. (2011) Presence of galactosylated core fucose on N-glycans in the planaria Dugesia japonica. J. Mass Spectrometry, 46: 561-567.

  11. Komatsu, S., Yamamoto, A., Nakamura, T., Nouri, M.-Z., Nanjo, Y., Nishizawa, K., and Furukawa, K. (2011) A comprehensive analysis of proteins and metabolites in roots and hypocotyls of soybean under flooding stress using proteomics and metabolomics techniques. J. Proteome Res., 10: 3993-4004.

  12. Kumagai, T., Sato, T., Natsuka, S., Kobayashi, Y., Zhou, D., Shinkai, T., Hayakawa, S., and Furukawa, K. (2010) Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthase. Glycoconj. J. 27: 685-695.

  13. Komatsu, S., Kobayashi, Y., Nishizawa, M, Nanjo, Y., and Furukawa, K. (2010) Comparative proteomics analysis of differentially expressed proteins in soybean cell wall during flooding stress. Amino Acids 39: 1435-1449.

  14. Miyazaki, T., Sato, T., Furukawa, K., and Ajisaka, K. (2010) Enzymatic synthesis of lacto-N-difucohexaose I which binds to Helicobacter pylori. Methods Enzymol. 48: 511-524.

  15. Tadokoro, T., Ikekita, M., and Furukawa, K. (2008) Disappearance of VCAM-1 from SV40 virus-transformed mouse Balb/3T3 cells. Res. Commun. Biochem. Cell & Molec. Biol., 14:113-122.

  16. Furukawa, K., and Tadokoro, T. (2009)Cellular aging and N-glycosylation of cell surface proteins. Res. Commun. Biochem. Cell & Molec. Biol., 13:41-52.

  17. Kitamura, N., Ikekita, M., and Furukawa, K. (2009) Involvement of tyrosine-phosphorylation in growth arrest of human neuroblastoma SH-SY5Y cells upon culture in Psathyrella velutina lectin-coated dishes. Res. Commun. Biochem. Cell & Molec. Biol., 105-112.

  18. Tadokoro, T., Ikekita, M., Toda, T., Ito. H., Sato, T., Nakatani, R., Hamaguchi, Y., and Furukawa, K. (2009) Involvement of galectin-3 with vascular cell adhesion molecule-1 in growth regulation of mouse Balb/3T3 cells. J. Biol. Chem. 284, 35556-25563.

  19. Kumagai, T., Tanaka, M., Yokoyama, M., Sato, T., Shinkai, T., and Furukawa, K. (2009) Early lethality of β-1,4-galactosyltransferase V-mutant mice by growth retardation. Biochem. Biophys. Res. Commun. 379 (2), 456-459.

  20. Sato, T., Takahashi, M., and Furukawa, K. (2008) β-1,4-Galactosyltransferase III is involved in the biosynthesis of highly branched N-linked oligosaccharides in WI38 human lung embryonic fibroblastic cells. Res. Commun. Biochem. Cell & Molec. Biol. 12 (1-2), 61-71.


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